Agrimonia pilosa leaf extract accelerates skin barrier restoration by activation of transient receptor potential vanilloid 3

Transient Receptor Potential Vanilloid

Activation of transient receptor potential vanilloid 3 by the methanolic extract of Schisandra chinensis fruit and its chemical constituent gschisandrin

Author contributions: Y.N. and H.J.K. performed the patch clamp experiments. Y.M.K. performed the chemical isolation from the plant extract. Y.W.C., Y.K.K. and H.S.B. supervised and coordinated the study. J.H.N. and W.K.K. worte the manuscript. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-co...

Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis.

Blockade of the transient receptor potential channel vanilloid subfamily 1 (TRPV1) is suggested as a therapeutic approach to pain relief. However, TRPV1 is a widely expressed protein whose function might be critical in various nonneuronal physiologic conditions. The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is overexpressed in many human epithelial cancers and i...

Transient Receptor Potential Vanilloid 1

Background and structure Transient receptor potential vanilloid receptor 1 (TRPV1) is one of 6 members of the subfamily of vanilloid receptors that belongs to the family of transient receptor potential (TRP) channels. TRP channels are an intrinsic part of the mammalian sensory system responding to a broad range of stimuli such as temperature, touch, pain, osmolarity, pheromones, and taste (8). ...

Acetylcholinesterase inhibition by flavonoids from Agrimonia pilosa.

In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which...